Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat
Identifieur interne : 000516 ( Main/Exploration ); précédent : 000515; suivant : 000517Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat
Auteurs : Arinjay Banerjee ; Darryl Falzarano ; Noreen Rapin ; Jocelyne Lew ; Vikram MisraSource :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Facteur-3 de régulation d'interféron (génétique), Facteur-3 de régulation d'interféron (immunologie), Humains, Immunité innée, Interféron bêta (immunologie), Lignée cellulaire, Phylogénie, Rein (cytologie), Rein (virologie), Techniques de knock-down de gènes, Techniques de knock-out de gènes, Transduction du signal, Échappement immunitaire.
- MESH :
- cytologie : Rein.
- génétique : Facteur-3 de régulation d'interféron.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Facteur-3 de régulation d'interféron, Interféron bêta.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chiroptera, Rein.
- Animaux, Humains, Immunité innée, Lignée cellulaire, Phylogénie, Techniques de knock-down de gènes, Techniques de knock-out de gènes, Transduction du signal, Échappement immunitaire.
English descriptors
- KwdEn :
- Animals, Cell Line, Chiroptera (virology), Gene Knockdown Techniques, Gene Knockout Techniques, Humans, Immune Evasion, Immunity, Innate, Interferon Regulatory Factor-3 (genetics), Interferon Regulatory Factor-3 (immunology), Interferon-beta (immunology), Kidney (cytology), Kidney (virology), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Phylogeny, Signal Transduction.
- MESH :
- chemical , genetics : Interferon Regulatory Factor-3.
- chemical , immunology : Interferon Regulatory Factor-3, Interferon-beta.
- cytology : Kidney.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- virology : Chiroptera, Kidney.
- Animals, Cell Line, Gene Knockdown Techniques, Gene Knockout Techniques, Humans, Immune Evasion, Immunity, Innate, Phylogeny, Signal Transduction.
Abstract
Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop signs of disease, we tested the hypothesis that MERS-CoV would replicate less efficiently in bat cells than in human cells because of its inability to subvert antiviral responses in bat cells. We infected human and bat (
Url:
DOI: 10.3390/v11020152
PubMed: 30781790
PubMed Central: 6410008
Affiliations:
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Le document en format XML
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sort="Lew, Jocelyne" uniqKey="Lew J" first="Jocelyne" last="Lew">Jocelyne Lew</name><affiliation><nlm:aff id="af2-viruses-11-00152">Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-Intervac), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada;<email>jocelyne.lew@usask.ca</email></nlm:aff></affiliation></author><author><name sortKey="Misra, Vikram" sort="Misra, Vikram" uniqKey="Misra V" first="Vikram" last="Misra">Vikram Misra</name><affiliation><nlm:aff id="af1-viruses-11-00152">Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada;<email>banera9@mcmaster.ca</email> (A.B.);<email>darryl.falzarano@usask.ca</email> (D.F.);<email>noreen.rapin@usask.ca</email> (N.R.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30781790</idno><idno type="pmc">6410008</idno><idno 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Saskatoon, SK S7N 5B4, Canada;<email>banera9@mcmaster.ca</email> (A.B.);<email>darryl.falzarano@usask.ca</email> (D.F.);<email>noreen.rapin@usask.ca</email> (N.R.)</nlm:aff></affiliation></author><author><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><affiliation><nlm:aff id="af1-viruses-11-00152">Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada;<email>banera9@mcmaster.ca</email> (A.B.);<email>darryl.falzarano@usask.ca</email> (D.F.);<email>noreen.rapin@usask.ca</email> (N.R.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-viruses-11-00152">Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-Intervac), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada;<email>jocelyne.lew@usask.ca</email></nlm:aff></affiliation></author><author><name sortKey="Rapin, Noreen" sort="Rapin, Noreen" uniqKey="Rapin N" first="Noreen" last="Rapin">Noreen Rapin</name><affiliation><nlm:aff id="af1-viruses-11-00152">Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada;<email>banera9@mcmaster.ca</email> (A.B.);<email>darryl.falzarano@usask.ca</email> (D.F.);<email>noreen.rapin@usask.ca</email> (N.R.)</nlm:aff></affiliation></author><author><name sortKey="Lew, Jocelyne" sort="Lew, Jocelyne" uniqKey="Lew J" first="Jocelyne" last="Lew">Jocelyne Lew</name><affiliation><nlm:aff id="af2-viruses-11-00152">Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-Intervac), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada;<email>jocelyne.lew@usask.ca</email></nlm:aff></affiliation></author><author><name sortKey="Misra, Vikram" sort="Misra, Vikram" uniqKey="Misra V" first="Vikram" last="Misra">Vikram Misra</name><affiliation><nlm:aff id="af1-viruses-11-00152">Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada;<email>banera9@mcmaster.ca</email> (A.B.);<email>darryl.falzarano@usask.ca</email> (D.F.);<email>noreen.rapin@usask.ca</email> (N.R.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chiroptera (virology)</term><term>Gene Knockdown Techniques</term><term>Gene Knockout Techniques</term><term>Humans</term><term>Immune Evasion</term><term>Immunity, Innate</term><term>Interferon Regulatory Factor-3 (genetics)</term><term>Interferon Regulatory Factor-3 (immunology)</term><term>Interferon-beta (immunology)</term><term>Kidney (cytology)</term><term>Kidney (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Phylogeny</term><term>Signal Transduction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Facteur-3 de régulation d'interféron (génétique)</term><term>Facteur-3 de régulation d'interféron (immunologie)</term><term>Humains</term><term>Immunité innée</term><term>Interféron bêta (immunologie)</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Rein (cytologie)</term><term>Rein (virologie)</term><term>Techniques de knock-down de gènes</term><term>Techniques de knock-out de gènes</term><term>Transduction du signal</term><term>Échappement immunitaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon Regulatory Factor-3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon Regulatory Factor-3</term><term>Interferon-beta</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rein</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur-3 de régulation d'interféron</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteur-3 de régulation d'interféron</term><term>Interféron bêta</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Kidney</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Gene Knockdown Techniques</term><term>Gene Knockout Techniques</term><term>Humans</term><term>Immune Evasion</term><term>Immunity, Innate</term><term>Phylogeny</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité innée</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Techniques de knock-down de gènes</term><term>Techniques de knock-out de gènes</term><term>Transduction du signal</term><term>Échappement immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop signs of disease, we tested the hypothesis that MERS-CoV would replicate less efficiently in bat cells than in human cells because of its inability to subvert antiviral responses in bat cells. We infected human and bat (<italic>Eptesicus fuscus</italic>) cells with MERS-CoV and observed that the virus grew to higher titers in human cells. MERS-CoV also effectively suppressed the antiviral interferon beta (IFNβ) response in human cells, unlike in bat cells. To determine if IRF3, a critical mediator of the interferon response, also regulated the response in bats, we examined the response of IRF3 to poly(I:C), a synthetic analogue of viral double-stranded RNA. We observed that bat IRF3 responded to poly(I:C) by nuclear translocation and post-translational modifications, hallmarks of IRF3 activation. Suppression of IRF3 by small-interfering RNA (siRNA) demonstrated that IRF3 was critical for poly(I:C) and MERS-CoV induced induction of IFNβ in bat cells. Our study demonstrates that innate antiviral signaling in <italic>E. fuscus</italic> bat cells is resistant to MERS-CoV-mediated subversion.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moratelli, R" uniqKey="Moratelli R">R. Moratelli</name></author><author><name sortKey="Calisher, C H" uniqKey="Calisher C">C.H. Calisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calisher, C H" uniqKey="Calisher C">C.H. Calisher</name></author><author><name sortKey="Childs, J E" uniqKey="Childs J">J.E. Childs</name></author><author><name sortKey="Field, H E" uniqKey="Field H">H.E. 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Baker</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Banerjee, Arinjay" sort="Banerjee, Arinjay" uniqKey="Banerjee A" first="Arinjay" last="Banerjee">Arinjay Banerjee</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Lew, Jocelyne" sort="Lew, Jocelyne" uniqKey="Lew J" first="Jocelyne" last="Lew">Jocelyne Lew</name><name sortKey="Misra, Vikram" sort="Misra, Vikram" uniqKey="Misra V" first="Vikram" last="Misra">Vikram Misra</name><name sortKey="Rapin, Noreen" sort="Rapin, Noreen" uniqKey="Rapin N" first="Noreen" last="Rapin">Noreen Rapin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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